Mammalian cells are the best at making recombinant proteins that can be used in medicine. They are very good at folding proteins properly and making changes that make the protein more like a human after it is made.
It’s interesting that up until now, all cell lines used to make biopharmaceutical proteins have been from animals. So, want to know more about how mammalian cells culture and the benefits you’ll get from them? If yes, then binge on till the end!
Table of Contents
You need some cells, to begin with. Now, there are mainly two types of cells:
These are called “Cell Lines.” Usually, dishes or plates (made of a special material) are often used to give these cells a certain place to live.
Moreover, cells require a certain soup to grow and thrive. And it’s called “culture media” soup, and it’s full of sugars, amino acids, and vitamins. Fetal bovine serum (FBS) is another thing that scientists add to aid these cells in growing even better.
But whatever process is conducted, sterilization is a must! Everything needs to be very clean so that bacteria or any other foreign particles don’t interfere. Scientists use methods like cleaning and heating to ensure that the soup and all of the tools are pretty clean.
Once all these are done, it’s time to move the cells into their new home. Researchers usually count the cells and then put a certain amount of them into the flask or dish. In general, cells like a warm environment, so they are always put in a place that is damp and has the right carbon dioxide levels.
As the cells get bigger, scientists gradually transfer them to a far bigger area with new soup. This gives the cells free space to move around. Now, researchers will keep a close eye on the cells to ensure they’re perfectly healthy and unharmed.
To ensure everything is in process, certain tests are carried out. These cells are used by researchers for many different types of tests, such as producing proteins, studying genes, and trying new drugs.
The section here will entirely focus on the possible benefits of mammalian cell culture for biologics manufacturing.
For instance, monoclonal antibodies and many other biopharmaceuticals need proteins that are very similar to proteins that people naturally make. As they come mainly from animals, mammalian cells can make these proteins perfectly.
Now, after going through this blog, you should have a clear idea of the mammalian cell culture and how it actually works in the biopharma industry. The benefits it brings are uncountable and it can be said that mammalian cell culture has been one of the biggest breakthroughs in the biopharma industry.
Originally posted 2023-10-27 23:23:06.
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